Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells
Ivana Vasic, Ashley R.G. Libby, Annie Maslan, Emily A. Bulger, David Zalazar, Martina Z. Krakora Compagno, Aaron Streets, Kiichiro Tomoda, Shinya Yamanaka, Todd C. McDevitt
Topics & Concepts
BiologyGerm layerInduced pluripotent stem cellCell biologyGastrulationMorphogenesisStem cellTight junctionEpiblastWnt signaling pathwayCellular differentiationEmbryonic stem cellSignal transductionEmbryoGeneticsEmbryogenesisGeneCancer-related gene regulationEpigenetics and DNA MethylationDevelopmental Biology and Gene Regulation