The histone deacetylase inhibitor PCI-24781 impairs calcium influx and inhibits proliferation and metastasis in breast cancer
Tianshu Yang, Pei Wang, Xin Yin, Jingyao Zhang, Miaomiao Huo, Jie Gao, Gen Li, Xu Teng, Hefen Yu, Wei Huang, Yan Wang
Abstract
: We have demonstrated that PCI-24781 is an effective anti-tumor therapeutic agent that targets calcium signaling by activating RGS2. This study also provides a novel perspective into the use of HDAC inhibitors for cancer therapy.
Topics & Concepts
Cancer researchMetastasisHistone deacetylaseHistone deacetylase inhibitorBreast cancerConventional PCICalciumMedicineBreast cancer metastasisChemistryCancerHistoneCancer metastasisInternal medicineBiochemistryMyocardial infarctionGeneHistone Deacetylase Inhibitors ResearchSignaling Pathways in DiseaseNuclear Receptors and Signaling