Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release
Lei Xu, Mengyuan Li, Yadong Yang, Chen Zhang, Zhen Xie, Jingjing Tang, Zhenkun Shi, Shukun Chen, Guangzhe Li, Yanchao Gu, Xiao Wang, Fuhua Zhang, Yao Wang, Xihui Shen
Abstract
As one of the most common foodborne transmitted zoonotic pathogens, S. Typhimurium infection causes diarrheal disease in humans and animals. S. Typhimurium infection has been implicated as an inducer for the type I interferon (IFN) response in macrophages, but the mechanisms are not fully understood. In this study, we reported that in addition to TLR4-dependent response, the cytosolic surveillance pathway (CSP) cGAS-STING is also required for the activation of type I IFN response during S. Typhimurium infection.
Topics & Concepts
MicrobiologySalmonellaInterferonStingBiologyTLR4VirologyInterferon type IImmunologyImmune systemBacteriaGeneticsEngineeringAerospace engineeringinterferon and immune responsesViral Infections and VectorsImmune Response and Inflammation