Tannic Acid-Assisted Synthesis of Biodegradable and Antibacterial Mesoporous Organosilica Nanoparticles Decorated with Nanosilver
Yue Zhang, Yan He, Chengxin Shi, Madi Sun, Chao Yang, Haijun Li, Fangman Chen, Zhimin Chang, Xiao Zheng, Zheng Wang, Wen‐Fei Dong, Junjun She, Dan Shao
Abstract
Metal/silica nanoparticles (NPs) have long been used as antibacterial substitutes; however, fabrication of a degradable carrier for achieving sustained release profile, high bactericidal efficacy, and good biocompatibility is still a challenge. Herein, we fabricated nanosilver-decorated biodegradable mesoporous organosilica nanoparticles (MONs) using a biocompatible natural polyphenol, tannic acid (TA), as not only a nonsurfactant template to form MONs but also a reducible agent to generate nanosilvers. Such a straightforward and green one-pot method does not need prior synthesis of silver NPs, removal of template, and use of toxic reducing agents. The resulting Ag-MONs with a well-distributed nanosilver exhibited a matrix-degradation-based silver ions release in response to glutathione (GSH), resulting in a stronger antibacterial effect with nondegradable Ag-mesoporous silica nanoparticles (MSNs), Ag NPs, and silver nitrate on Escherichia coli and Staphylococcus aureus. Moreover, Ag-MONs show better biocompatibility than the Ag NPs and silver nitrate at the same silver dose. Our findings have provided a facile and economical route to fabricate nanosilver-decorated biodegradable mesoporous organosilica nanoparticles. These nanoparticles showed promising applications in the fields of biomedicine and catalysis.