Polydopamine functionalized VEGF gene-activated 3D printed scaffolds for bone regeneration
Jaidev Chakka, Timothy M. Acri, Noah Z. Laird, Ling Zhong, Kyungsup Shin, Satheesh Elangovan, Aliasger K. Salem
Abstract
rat calvarial critical bone defect model demonstrated 1.6-fold higher new bone formation compared to the PLA-PDA scaffold. H&E and Masson's trichrome staining of bone sections also revealed that the PLA-PDA-PEI-pVEGF scaffold facilitated the formation of more blood vessels in the newly formed bone compared to the PLA and PLA-PDA scaffold groups. Thus, PLA-PDA-PEI-pVEGF might be a potential 3D printed gene activated scaffold for bone regeneration in clinical situations.
Topics & Concepts
Regeneration (biology)VEGF receptors3d printedChemistryCell biologyCancer researchBiologyBiomedical engineeringMedicineBone Tissue Engineering Materials3D Printing in Biomedical ResearchGraphene and Nanomaterials Applications