Self-assembling peptide P<sub>11</sub>-4 in remineralization of enamel caries – a systematic review of <i>in-vitro</i> studies
Roshan Noor Mohamed, Sakeenabi Basha, Yousef Al-Thomali, Ammar Saleh Alshamrani, Fatma Salem Alzahrani, Enas Tawfik Enan
Abstract
OBJECTIVE: -4 in the remineralization of enamel caries. MATERIAL AND METHODS: The systematic search for studies was conducted through CINAHL, EMBASE, MEDLINE, Scopus, PsychINFO, and various key journals. This review was conducted in adherence to PRISMA standards and was registered in PROSPERO with registration number CRD42019110156. The methodological quality of the studies was graded through Cochrane's tool of risk of bias in non-randomized studies - of interventions (ROBINS-I). RESULTS: -4 alone. Quality assessment of study showed 6 (50%) studies as medium risk of bias and 6 (50%) studies as low risk of bias. CONCLUSION: -4 is effective in the remineralization of enamel caries.