Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and <i>in vitro</i> and <i>in vivo</i> breast cancer biological assays
Menna M. Abdelshaheed, Hussein I. El‐Subbagh, Mohamed A. Tantawy, Reem T. Attia, Khairia M. Youssef, Iten M. Fawzy
Abstract
Compound 3b was designed and synthesized as pyrano-pyridine hybrid that showed high potency in the in vitro antiproliferative assay, 81% inhibition to polymerization of tubulin, high dynamic stability and 79% reduction in tumor size of breast cancer in vivo assay.
Topics & Concepts
In vivoChemistryPyridineIn vitroIC50MTT assayTubulinCancer cellLead compoundStereochemistryCancerBiochemistryMicrotubuleBiologyOrganic chemistryCell biologyGeneticsBiotechnologySynthesis and biological activityClick Chemistry and ApplicationsCancer therapeutics and mechanisms