PPARγ and C/EBPα response to acute cold stress in brown adipose tissue
Kin H. Lau, Althea Waldhart, Holly Dykstra, Tracey Avequin, Ning Wu
Abstract
enhancers, leading to decreased C/EBPα expression. This dissociation requires PPARγ binding to activating ligands and is thus modulated by diet. Meanwhile, PPARα also detaches from DNA, and co-activator PGC1α associates with ERRα as part of a transcriptional network regulating lipid metabolism. Subsequent global replacement of C/EBPα by C/EBPβ and its associated transcriptional machinery is required for upregulation of structural lipid synthesis despite general upregulation of fatty acid oxidation.
Topics & Concepts
ThermogenesisAdipogenesisDownregulation and upregulationBrown adipose tissueCcaat-enhancer-binding proteinsPeroxisome proliferator-activated receptorChemistryAdipose tissueReceptorActivator (genetics)Cell biologyNuclear receptorLipid metabolismPeroxisomePRDM16EndocrinologyInternal medicineTranscription factorBiologyBiochemistryDNA-binding proteinGeneMedicineAdipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases