Two new diterpenoids from<i>Penicillium chrysogenum</i>MT-12, an endophytic fungus isolated from<i>Huperzia serrata</i>
Bowen Qi, Fangfang Jia, Yuan Luo, Ning Ding, Sainan Li, Fanyu Shi, Yan Hai, Lili Wang, Zhixiang Zhu, Xiao Liu, Pengfei Tu, Shepo Shi
Abstract
Two new diterpenoids, penicichrysogene A (1) and penicichrysogene B (2), were isolated from the solid substrate fermentation cultures of Penicillium chrysogenum MT-12, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Their structures were elucidated on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR, UV, IR, and HRESIMS). The absolute configurations of 1 and 2 were assigned on the basis of experimental and calculated electronic circular dichroism spectra. Compound 1 exhibited inhibitory activity on ATP release of thrombin-activated platelets with IC50 = 42.7 ± 3.5 μM.