First Example of Catalytic Synthesis of Cyclic S-Containing Di- and Triperoxides
Nataliya N. Makhmudiyarova, I. R. Ishmukhametova, Lilya U. Dzhemileva, Vladimir A. D’yakonov, А. Г. Ибрагимов, У. М. Джемилев
Abstract
An efficient method for the synthesis of tetraoxathiaspiroalkanes, tetraoxathiocanes, and hexaoxathiadispiroalkanes was developed by reactions of pentaoxacanes, pentaoxaspiroalkanes, and heptaoxadispiroalkanes with hydrogen sulfide in the presence of a catalyst, Sm(NO3)3·6H2O. We found that the synthesized S-containing di- and triperoxides exhibit high cytotoxic activity against Jurkat, K562, U937, and HL60 tumor cultures, and fibroblasts.
Topics & Concepts
Jurkat cellsCatalysisHydrogen sulfideHL60Cytotoxic T cellChemistryK562 cellsSulfideCombinatorial chemistryMedicinal chemistryOrganic chemistryBiologyCellBiochemistryT cellImmunologyIn vitroImmune systemSulfurChemical Synthesis and ReactionsSynthesis and Reactivity of Sulfur-Containing CompoundsSulfur-Based Synthesis Techniques