Kv Channel Ancillary Subunits: Where Do We Go from Here?
Geoffrey W. Abbott
Abstract
Voltage-gated potassium (Kv) channels each comprise four pore-forming α-subunits that orchestrate essential duties such as voltage sensing and K + selectivity and conductance. In vivo, however, Kv channels also incorporate regulatory subunits—some Kv channel specific, others more general modifiers of protein folding, trafficking, and function. Understanding all the above is essential for a complete picture of the role of Kv channels in physiology and disease.
Topics & Concepts
Potassium channelConductanceCell biologyVoltage-gated potassium channelBiophysicsProtein subunitChemistryChannel (broadcasting)BiologyNeuroscienceBiochemistryComputer scienceGenePhysicsComputer networkCondensed matter physicsIon channel regulation and functionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research