<scp>Alpha‐Synuclein RT‐QuIC</scp> in Idiopathic Normal Pressure Hydrocephalus
Alfonso Fasano, Iván Martínez-Valbuena, Paula Azevedo, Carolina Candeias da Silva, Musleh Algarni, Anna Vasilevskaya, Chloe Anastassiadis, Foad Taghdiri, Paul Kongkham, Ivan Radovanovic, Gelareh Zadeh, Anthony E. Lang, David F. Tang‐Wai, Gábor G. Kovács, Maria Carmela Tartaglia
Abstract
This study quantified the occurrence of an underlying synucleinopathy in 50 patients with idiopathic normal pressure hydrocephalus by means of real-time quaking-induced conversion, a highly sensitive and specific technique capable of detecting and amplifying misfolded aggregated forms of α-synuclein in the cerebrospinal fluid. Seven patients were positive and they did not differ from negative cases, except for a more frequent L-dopa responsiveness and gait characterized by a wider base. The two groups did not differ in terms of response rate to tap test or shunt surgery, although step length and gait velocity improved by a lesser extent in positive cases. ANN NEUROL 2022;92:985-991.