HFIP-mediated three-component imidization of electron-rich arenes with <i>in situ</i> formed spiroindolenines for facile construction of 2-arylspiroindolenines
Chunyan Ge, Liang Wang, Fangzhi Hu, Zhanshuai Ding, Xinyao Li, Deshuai Xiao, Jiayi Wang, Shuai‐Shuai Li
Abstract
The three-component reaction of o -aminobenzaldehydes with 5-hydroxyindole and electron-rich arenes has been achieved through HFIP-mediated cascade hydride transfer/dearomative cyclization/CDC-type imidization at room temperature under air.
Topics & Concepts
ChemistryHydrideCascadeIn situComponent (thermodynamics)Electron transferCombinatorial chemistryElectronPolymer chemistryPhotochemistryOrganic chemistryMetalQuantum mechanicsChromatographyPhysicsThermodynamicsCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis of Indole Derivatives