Electrochemical Decarboxylative <i>N</i>-Alkylation of Heterocycles
Tao Sheng, Hai‐Jun Zhang, Ming Shang, Chi He, Julien C. Vantourout, Phil S. Baran
Abstract
An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.
Topics & Concepts
ChemistryAlkylationCombinatorial chemistryElectrochemistrySubstrate (aquarium)Scope (computer science)AnodeOrganic chemistryCatalysisComputer scienceElectrodePhysical chemistryGeologyProgramming languageOceanographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis