Cold acclimation and pioglitazone combined increase thermogenic capacity of brown and white adipose tissues but this does not translate into higher energy expenditure in mice
Luis Felipe Valdivia, Érique Castro, Rosangela Aparecida dos Santos Eichler, Mayara Franzoi Moreno, Érica de Sousa, Giovanna Freitas Rodrigues Jardim, Álbert S. Peixoto, Maria Nathália Moraes, Ana Maria de Lauro Castrucci, Jan Nedergaard, Nataša Petrovič, William T. Festuccia, Patrícia Reckziegel
Abstract
Cold acclimation and PPARγ agonism combined markedly increase brown and white adipose tissue total UCP1 content and mRNA levels of thermogenesis-related proteins. Higher UCP1 protein levels did not result in higher energy expenditure. The high thermogenic capacity induced by PPARγ agonism in cold-exposed animals markedly increases animals' body temperature in response to the β3-adrenergic agonist CL316,243.
Topics & Concepts
Brown adipose tissuePioglitazoneEndocrinologyWhite adipose tissueInternal medicineThermogenesisThermogeninAdipose tissueGLUT4BiologyChemistryGlucose uptakeType 2 diabetesInsulinDiabetes mellitusMedicineAdipose Tissue and MetabolismExercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases