Exosome-based <i>Ldlr</i> gene therapy for familial hypercholesterolemia in a mouse model
Zhelong Li, Ping Zhao, Yajun Zhang, Jia Wang, Chen Wang, Yunnan Liu, Guodong Yang, Lijun Yuan
Abstract
mouse. Our study provided a new therapeutic approach for the treatment of FH patients and managing atherosclerosis.
Topics & Concepts
LDL receptorFamilial hypercholesterolemiaMicrovesiclesExosomePCSK9ReceptorOil Red OLipoproteinMessenger RNACholesterolInternal medicineEndocrinologyBiologyChemistryMedicinemicroRNAGeneBiochemistryAdipose tissueAdipogenesisViral Infections and Immunology ResearchLipoproteins and Cardiovascular HealthRNA Research and Splicing