Sensitive and specific assay for the serological diagnosis of anti-p200 pemphigoid based on the recombinant laminin β4 subunit
Stephanie Goletz, Christian Probst, Lars Komorowski, Christiane Radzimski, Swantje Mindorf, Maike M. Holtsche, Manuela Pigors, Nina van Beek, Detlef Zillikens, Wolfgang Schlumberger, Enno Schmidt
Abstract
Anti-p200 pemphigoid is an autoimmune blistering disease that often resembles other pemphigoid disorders. We developed a test for the detection of autoantibodies against laminin β4, an autoantigen in anti-p200 pemphigoid, to facilitate its diagnosis. The test demonstrated excellent sensitivity and specificity, making it a valuable tool for diagnosing this disease and distinguishing it from similar skin disorders.
Topics & Concepts
PemphigoidRecombinant DNAP200MedicineLamininBullous pemphigoidSerologyImmunologyAutoantibodyDermatologyAntibodyChemistryBiologyBiochemistryGeneCellNeurosciencePerceptionVisual perceptionAutoimmune Bullous Skin DiseasesCoagulation, Bradykinin, Polyphosphates, and AngioedemaUrticaria and Related Conditions