The type V myosin-containing complex HUM is a RAB11 effector powering movement of secretory vesicles
Mario Pinar, Ana Alonso, Vivian de los Rı́os, Ignacio Bravo-Plaza, Álvaro de la Gándara, Antonio Galindo, Ernesto Arias‐Palomo, Miguel Á. Peñalva
Abstract
. Ablating UDS1 or HMSV impairs actomyosin-mediated transport of SVs to the apex, resulting in spreading of RAB11 SVs across the apical dome as KinA/microtubule-dependent transport gains prominence.
Topics & Concepts
GTP'VesicleKinesinMotor proteinMolecular motorCoiled coilMyosinBiophysicsCell biologyBiologyChemistryMicrotubuleBiochemistryMembraneEnzymeCellular transport and secretionFungal and yeast genetics researchEndoplasmic Reticulum Stress and Disease