Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy
Xuedong Li, Xingang Liu, Songsong Wang, Xiaoxing Shi, Ming Lü, Xinyue Hao, Yan Fu, Yang Zhang, Qingzhong Jia, Dian He
Topics & Concepts
PharmacophoreChemistryHDAC6EnzymeInhibitory postsynaptic potentialEnzyme inhibitionBiochemistryComputational biologyHistone deacetylaseHistoneBiologyGeneNeuroscienceHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisProtein Degradation and Inhibitors