Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells through PI3K/AKT pathway
Xuguang Li, Shuchan Sun, Di Chen, Tianyi Yuan, Yucai Chen, Danshu Wang, Lian‐Hua Fang, Yang Lu, Guanhua Du
Topics & Concepts
PuerarinProtein kinase BPI3K/AKT/mTOR pathwayOxidative stressDownregulation and upregulationCardiac fibrosisCell biologyEpithelial–mesenchymal transitionChemistrySignal transductionEndothelial stem cellLY294002BiologyFibrosisMedicineBiochemistryInternal medicinePathologyIn vitroGeneAlternative medicineCardiac Fibrosis and RemodelingCongenital heart defects researchNitric Oxide and Endothelin Effects