Conjugated linoleic acid (CLA) reduces intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway
Fenglin Zhang, Yiming Fu, Junfeng Wang, Limin Lang, Shuyi Liang, Shilei Zhang, Lina Wang, Ping Gao, Gang Shu, Canjun Zhu, Ruifan Wu, Qingyan Jiang, Songbo Wang
Abstract
verification, CLA supplementation reduced the DHHC7-mediated total and cell membrane CD36 palmitoylation and suppressed the formation of the CD36/FYN/LYN complex and the activation of the ERK pathway in the jejunum of HFD-fed mice. Altogether, these data showed that CLA reduced intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway.
Topics & Concepts
Conjugated linoleic acidCD36ChylomicronPalmitoylationChemistryLinoleic acidMAPK/ERK pathwayBiochemistryANGPTL4Fatty acidSignal transductionLipoproteinEnzymeCysteineCholesterolGeneVery low-density lipoproteinPeroxisome Proliferator-Activated ReceptorsDiet and metabolism studiesLiver Disease Diagnosis and Treatment