Tuning the Loading and Release Properties of MicroRNA-Silencing Porous Silicon Nanoparticles by Using Chemically Diverse Peptide Nucleic Acid Payloads
Martina Neri, Jinyoung Kang, Jonathan M. Zuidema, Jessica Gasparello, Alessia Finotti, Roberto Gambari, Michael J. Sailor, Alessandro Bertucci, Roberto Corradini
Abstract
silencing of a set of specific microRNAs using a pSiNP-PNA delivery platform demonstrates the potential for biomedical applications.
Topics & Concepts
Peptide nucleic acidNucleic acidOligonucleotideGene silencingPorous siliconInternalizationPeptideNanoparticleNanotechnologyMaterials scienceBiophysicsCombinatorial chemistryChemistrySiliconDNACellBiochemistryBiologyMetallurgyGeneAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliverySilicon Nanostructures and Photoluminescence