Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged duration of gene silencing effects of a GalNAc-conjugated human hypoxanthine phosphoribosyl transferase (HPRT1) siRNA
Qian Yang, Sara C. Humphreys, Julie M. Lade, Albert P. Li
Topics & Concepts
Gene silencingBiologyIn vitroGene expressionGeneRNA interferencePotencyMolecular biologyOligonucleotideSmall interfering RNACell cultureRNABiochemistryGeneticsBiochemical and Molecular ResearchCRISPR and Genetic EngineeringRNA Interference and Gene Delivery