Cascade Synthesis from Cyclohexane to ϵ‐Caprolactone by Visible‐Light‐Driven Photocatalysis Combined with Whole‐Cell Biological Oxidation
Peilin Li, Yunjian Ma, Yongru Li, Xizhen Zhang, Yonghua Wang
Abstract
Abstract Cyclohexane was directly oxy‐functionalised to ϵ‐caprolactone through a cascade reaction sequence combining visible‐light‐driven photocatalysis with cyclohexanone monooxygenase (CHMO) whole‐cell biocatalysis. Two available photocatalysts, Au‐doped TiO 2 (Au‐TiO 2 ) and graphitic carbonitride (g‐C 3 N 4 ), were evaluated in the experiment and some optimisations to the cascade reaction were applied. In stepwise mode, the highest degree of conversion from cyclohexanol to ϵ‐caprolactone can be up to 41 %, with use of g‐C 3 N 4 . The cascade reaction from cyclohexane to ϵ‐caprolactone is achievable under a light intensity of 149 μW cm −2 .
Topics & Concepts
CyclohexanoneCyclohexanePhotocatalysisCyclohexanolCaprolactoneCascadePhotochemistryCascade reactionChemistryVisible spectrumMaterials scienceCatalysisCombinatorial chemistryOrganic chemistryPolymerizationOptoelectronicsPolymerChromatographyAdvanced Photocatalysis TechniquesAdvanced Nanomaterials in CatalysisEnzyme Catalysis and Immobilization