Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo
Huachao Bin, Pei Chen, Ming Wu, Falu Wang, Guifeng Lin, Shulei Pan, Jingming Liu, Bo Mu, Jinshan Nan, Qiao Huang, Linli Li, Shengyong Yang
Topics & Concepts
In vivoKinaseChemistryAtaxia-telangiectasiaIn vitroDNA damageBiochemistryCancer researchPharmacologyDNABiologyGeneticsDNA Repair MechanismsCancer therapeutics and mechanismsCancer-related Molecular Pathways