Palladium-catalyzed stereoselective trifluoromethylated allylic alkylation of 3-substituted oxindoles
Dong Li, Shuaibo Zhang, Bangzhong Wang, Wuding Sun, Jinfeng Zhao, Jingping Qü, Yuhan Zhou
Abstract
The palladium-catalyzed asymmetric trifluoromethylated allylic alkylation of 3-substituted oxindoles using α-(trifluoromethyl)alkenyl acetates as trifluoromethyl-containing allyl precursors was developed.
Topics & Concepts
ChemistryTrifluoromethylPalladiumStereoselectivityTsuji–Trost reactionAllylic rearrangementCatalysisAlkylationOrganic chemistryMedicinal chemistryAlkylFluorine in Organic ChemistryAsymmetric Synthesis and CatalysisCyclopropane Reaction Mechanisms