Molecular Dynamics-Based Allosteric Prediction Method to Design Key Residues in Threonine Dehydrogenase for Amino-Acid Production
Mingyu Wu, Yu Sun, Meiru Zhu, Laiyu Zhu, Junhong Lü, Feng Geng
Abstract
for amino-acid production. These findings have proved the MBAP method as an effective and efficient predicting tool to find new positions of the allosteric enzymes, thus opening a new path to constructing cell factories in synthetic biology.
Topics & Concepts
Allosteric regulationAllosteric enzymeBiochemistryAspartate carbamoyltransferaseComputational biologyThreonineAmino acidChemistryIsoleucineStructural biologyEnzymeBiologySerineLeucineMicrobial Metabolic Engineering and BioproductionPancreatic function and diabetesEnzyme Structure and Function