Role of peripheral immune cells in spinal cord injury
Cong Li, Wu Xiong, Bowen Wan, Guang Kong, Siming Wang, Yingying Wang, Jin Fan
Abstract
Secondary spinal cord injury is caused by an inflammatory response cascade, and the process is irreversible. The immune system, as a mediator of inflammation, plays an important role in spinal cord injury. The spinal cord retains its immune privilege in a physiological state. Hence, elucidating the mechanisms by which peripheral immune cells are recruited to the lesion site and function after spinal cord injury is meaningful for the exploration of clinical therapeutic targets. In this review, we provide an overview of the multifaceted roles of peripheral immune cells in spinal cord injury.
Topics & Concepts
PeripheralSpinal cordImmune systemSpinal cord injuryMedicineImmunologyPathologyBiologyNeuroscienceInternal medicineSpinal Cord Injury ResearchNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms