Carotid bodies mediate glial cell activation and neuroinflammation in the NTS following long-term intermittent hypoxia: role in cardiorespiratory dysfunction
Katherin V. Pereyra, Esteban Díaz‐Jara, Ignacio Bernal‐Santander, Sinay Vicencio, Rodrigo Del Río, Rodrigo Iturriaga
2025American Journal of Physiology-Lung Cellular and Molecular Physiology13 citationsDOIOpen Access PDF
Abstract
Chronic intermittent hypoxia (CIH), a feature of obstructive sleep apnea, causes cardiorespiratory alterations (i.e. hypertension) linked to oxidative stress, inflammation, and sympathoexcitation. In the present study, we highlight the role of enhanced carotid body (CB) chemosensory afferent discharges to the nucleus of the solitary tract (NTS) in long-term CIH-induced cardiorespiratory disorders. Indeed, we provide evidence that supports the notion that increased CB afferent activity contributes to persistent CIH-induced hypertension, likely triggering neuroinflammation in the NTS.
Topics & Concepts
Intermittent hypoxiaAstrocyteMedicineHypoxic ventilatory responseNeuroinflammationHypoxia (environmental)Cardiorespiratory fitnessMicrogliaCarotid bodyObstructive sleep apneaEndocrinologyBlood pressureInternal medicineAnesthesiaRespiratory systemChemistryCentral nervous systemInflammationStimulationOxygenOrganic chemistryNeuroscience of respiration and sleepObstructive Sleep Apnea ResearchSleep and Wakefulness Research