Palladium Metallaphotoredox-Catalyzed 2-Arylation of Indole Derivatives
Xinmou Wang, Xiwei Xun, Hongjian Song, Yuxiu Liu, Qingmin Wang
Abstract
Given that biaryl motifs are found in many useful molecules, including pesticides, pharmaceuticals, functional materials, and polymers, the development of methods for their construction is important. Herein, we report a two-step method for C(sp2)–H/C(sp2)–H cross-coupling reactions to synthesize 2-arylindole derivatives by combining palladium catalysis and photocatalysis. This mild, dual-catalysis method showed good functional group tolerance and a wide substrate scope and could be used for late-stage functionalization of oligopeptides, drugs, and natural products.
Topics & Concepts
ChemistryPalladiumIndole testCatalysisCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsOxidative Organic Chemistry Reactions