Electrochemical Synthesis of α-Ketoamides under Catalyst-, Oxidant-, and Electrolyte-Free Conditions
Jinyang Chen, Hongyu Wu, Qingwen Gui, Xiao-Ran Han, Yan Wu, Kui Du, Zhong Cao, Ying‐Wu Lin, Wei‐Min He
Abstract
A catalyst-, oxidant-, electrolyte-free method for the preparation of α-ketoamides through the direct electrochemical amidation of α-ketoaldehydes and amines with innocuous hydrogen as the sole byproduct at ambient temperature was developed. The present reaction features clean and mild conditions, excellent functional-group tolerance, and high atom economy and scalability, enabling facile applications in pharmaceutical chemistry.
Topics & Concepts
ChemistryElectrolyteCatalysisElectrochemistryAtom economyCombinatorial chemistryReaction conditionsOrganic chemistryElectrodePhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsCO2 Reduction Techniques and Catalysts