Pulsatile Basal Insulin Secretion Is Driven by Glycolytic Oscillations
Patrick A. Fletcher, Isabella Marinelli, Richard Bertram, Leslie S. Satin, Arthur Sherman
Abstract
In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose levels, comparatively little is known about its origin under basal conditions. We propose a possible mechanism for basal insulin oscillations based on oscillations in glycolysis, demonstrated using an established mathematical model. At high glucose, this is superseded by a calcium-dependent mechanism.
Topics & Concepts
Basal (medicine)InsulinGlycolysisInternal medicineEndocrinologyBasal insulinPulsatile flowInsulin oscillationCalciumSecretionMechanism (biology)BiologyMetabolismMedicineInsulin resistanceDiabetes mellitusPhysicsType 2 diabetesQuantum mechanicsPancreatic function and diabetesMetabolism, Diabetes, and CancerDiabetes Management and Research