Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19

Samuele Notarbartolo, Valeria Ranzani, Alessandra Bandera, Paola Gruarin, Valeria Bevilacqua, Anna Rita Putignano, Andrea Gobbini, Eugenia Galeota, Cristina Manara, Mauro Bombaci, Elisa Pesce, Elena Zagato, Andrea Favalli, Maria Lucia Sarnicola, Serena Maria Curti, Mariacristina Crosti, Martina Martinović, Tanya Fabbris, Fédérico Marini, Lorena Donnici, Mariangela Lorenzo, Marilena Mancino, Riccardo Ungaro, Andrea Lombardi, Davide Mangioni, Antonio Muscatello, Stefano Aliberti, Francesco Blasi, Tullia De Feo, Daniele Prati, Lara Manganaro, Francesca Granucci, Antonio Lanzavecchia, Raffaele De Francesco, Andrea Gori, Renata Grifantini, Sergio Abrignani

2021Science Immunology183 citationsDOI Open Access PDF

Abstract

Characterization of the immune responses to SARS-CoV-2 reveals a CD8 + T cell subset that likely establishes the memory to the virus.

Topics & Concepts

RepertoireImmune systemCoronavirus disease 2019 (COVID-19)Biology2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ImmunologyImmunophenotypingMedicineVirologyPathologyFlow cytometryDiseaseInfectious disease (medical specialty)AcousticsOutbreakPhysicsSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19