Malvidin and its derivatives exhibit antioxidant properties by inhibiting MAPK signaling pathways to reduce endoplasmic reticulum stress in ARPE-19 cells
Xinyao Liu, Fei Zheng, Sheng Li, Zhitong Wang, Xinyuan Wang, Wen Lian-kui, Yang He
Abstract
. Western blotting and immunofluorescence analysis revealed that MV, Mv3C, and Mv3ACEC regulate mitogen-activated protein kinase signal transduction pathways related to endoplasmic reticulum stress. Interestingly, Mv3C and Mv3ACEC showed greater beneficial properties than MV. Our results show that MV and its derivatives have potential as therapeutic compounds for ocular diseases associated with oxidative stress, such as age-related macular degeneration.
Topics & Concepts
Endoplasmic reticulumReactive oxygen speciesAntioxidantChemistryOxidative stressSuperoxide dismutaseMalondialdehydeBiochemistrySignal transductionMAPK/ERK pathwayGlutathioneGlutathione peroxidaseCell biologyBiologyEnzymeVitamin C and Antioxidants ResearchAutophagy in Disease and TherapySirtuins and Resveratrol in Medicine