Successful Treatment of <i>Balamuthia mandrillaris</i> Granulomatous Amebic Encephalitis with Nitroxoline
Natasha Spottiswoode, Douglas Pet, Annie Kim, Katherine Gruenberg, Maulik Shah, Amrutha Ramachandran, Matthew T. Laurie, Maham Zia, Camille Fouassier, Christine L. Boutros, Rufei Lu, Yueyuan Zhang, Venice Servellita, Andrew W. Bollen, Charles Y. Chiu, Michael R. Wilson, Liza Valdivia, Joseph L. DeRisi
Abstract
A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typically used to treat urinary tract infections, was identified in a screen for drugs with amebicidal activity against Balamuthia.
Topics & Concepts
MedicineQuinoloneVirologyMicrobiologyAntibioticsBiologyLegionella and Acanthamoeba researchAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and Efficacy