Convergent synthesis of bicyclic boronates <i>via</i> a cascade regioselective Suzuki–Miyaura/cyclisation protocol
Alessandro Marotta, Hannah M. Kortman, Chiara Interdonato, Peter H. Seeberger, John J. Molloy
Abstract
A regioselective cross-coupling/cyclisation reaction of vicinal boronic esters with 2-halophenols to forge 3-substituted bicyclic boronates is disclosed enabling access to drug derivatives and bicyclic boronates with a pendent biomolecular probe.
Topics & Concepts
RegioselectivityCascadeBicyclic moleculeChemistryProtocol (science)Combinatorial chemistryStereochemistryOrganic chemistryCatalysisChromatographyMedicineAlternative medicinePathologyChemical Synthesis and AnalysisCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods