Clinical characteristics of COVID-19 infection in chronic obstructive pulmonary disease: a multicenter, retrospective, observational study
Fan Wu, Yumin Zhou, Zhongfang Wang, Min Xie, Zhe Shi, Zhiqiang Tang, Xiaohe Li, Xiaochen Li, Chunliang Lei, Yimin Li, Zhengyi Ni, Yu Hu, Xiaoqing Liu, Wenguang Yin, Linling Cheng, Feng Ye, Jieqi Peng, Lingmei Huang, Jia Tian, Lingjuan Zhang, Xiaoneng Mo, Ying Zhang, Ke Hu, Yongliang Jiang, Wei‐jie Guan, Jie Xiang, Yingxia Liu, Yixiang Peng, Wei Li, Yahua Hu, Peng Peng, Jianming Wang, Jiyang Liu, Wei Huang, Ruchong Chen, Jianping Zhao, Shiyue Li, Nuofu Zhang, Jincun Zhao, Nanshan Zhong, Pixin Ran
Abstract
BACKGROUND: Coronavirus disease 2019 (COVID-19) has been a global pandemic disease, with more than 4 million cases and nearly 300,000 deaths. Little is known about COVID-19 in patients with chronic obstructive pulmonary disease (COPD). We aimed to evaluate the influence of preexisting COPD on the progress and outcomes of COVID-19. METHODS: This was a multicenter, retrospective, observational study. We enrolled 1,048 patients aged 40 years and above, including 50 patients with COPD and 998 patients without COPD, and with COVID-19 confirmed via high-throughput sequencing or real-time reverse transcription-polymerase chain reaction, between December 11, 2019 and February 20, 2020. We collected data of demographics, pathologic test results, radiologic imaging, and treatments. The primary outcomes were composite endpoints determined by admission to an intensive care unit, the use of mechanical ventilation, or death. RESULTS: 1.3%). Patients with COPD and COVID-19 had a higher risk of reaching the composite endpoints [hazard ratio (HR): 2.17, 95% confidence interval (CI): 1.40-3.38; P=0.001] or death (HR: 2.28, 95% CI: 1.15-4.51; P=0.019), after adjustment. CONCLUSIONS: In this study, patients with COPD who developed COVID-19 showed a higher risk of admission to the intensive care unit, mechanical ventilation, or death.