MiRNAs in cancers and renin-angiotensin-aldosterone system: Implications for chemoradiotherapy resistance
Ming Li, Chunhua Wang, Hengrui Liu, Zhijie Xu, Ying Liu
Abstract
Over the past few decades, a growing body of research has revealed that microRNAs (miRNAs) play a crucial role in regulating the majority of mammalian protein-coding genes. These genes, in turn, control a broad array of cellular processes, such as differentiation, development, proliferation, and cellular senescence, through various regulatory mechanisms. Dysregulations in the biogenesis and functions of miRNAs have been linked to multiple human diseases, including lung, breast, hepatocellular, gastric, colorectal, and cervical cancers. Meanwhile, this review also discusses how miRNA modifications influence cancer biology by modulating the renin-angiotensin-aldosterone system (RAAS). These findings underscore the significant potential of miRNAs in cancers chemoradiotherapy resistance and RAAS .The present review aims to elucidate the association between miRNAs and cancer therapy resistance, with the goal of deepening our understanding of complex therapeutic mechanisms and informing clinical treatment strategies.