Litter Commensal Bacteria Can Limit the Horizontal Gene Transfer of Antimicrobial Resistance to Salmonella in Chickens
Adelumola Oladeinde, Zaid Abdo, Benjamin Zwirzitz, Reed Woyda, Steven M. Lakin, Maximilian O. Press, N.A. Cox, Jesse C. Thomas, Torey Looft, Michael J. Rothrock, Gregory Zock, Jodie Plumblee Lawrence, Denice Cudnik, Casey W. Ritz, Samuel E. Aggrey, Ivan Liachko, Jonas Grove, Crystal J. Wiersma
Abstract
Antimicrobial resistance spread is a worldwide health challenge, stemming in large part from the ability of microorganisms to share their genetic material through horizontal gene transfer. To address this issue, many countries and international organizations have adopted a One Health approach to curtail the proliferation of antimicrobial-resistant bacteria. This includes the removal and reduction of antibiotics used in food animal production and the development of alternatives to antibiotics. However, there is still a significant knowledge gap in our understanding of how resistance spreads in the absence of antibiotic selection and the role commensal bacteria play in reducing antibiotic resistance transfer. In this study, we show that commensal bacteria play a key role in reducing the horizontal gene transfer of antibiotic resistance to Salmonella, provide the identity of the bacterial species that potentially perform this function in broiler chickens, and also postulate the mechanism involved.