Hemocompatible nucleosome-inspired heparin-mimicking hydrogel microspheres for safe and efficient extracorporeal removal of circulating histones in critically ill patients
Yu Chen, Tinghang Yang, Shujing Wang, Dongmei Tong, Xianda Liu, Yupei Li, Weifeng Zhao, Changsheng Zhao
Abstract
within 4 h. Moreover, the RCHMs significantly attenuate histone-mediated thrombocytopenia, platelet aggregation, and endothelial cell death. Therefore, the RCHMs are promising hemoperfusion adsorbents for extracorporeal removal of circulating histones from the blood of critically ill patients, providing a new insight into the management of multiple histone-related disorders.
Topics & Concepts
HeparinExtracorporealCritically illMicrosphereHistoneMaterials scienceIntensive care medicineMedicineChemical engineeringEngineeringChemistrySurgeryDNABiochemistryTissue Engineering and Regenerative MedicineNeonatal Respiratory Health ResearchElectrospun Nanofibers in Biomedical Applications