Direct Phosphonylation of N-Carbamate-tetrahydroisoquinoline by Convergent Paired Electrolysis
Stéphane Sengmany, Thierry Martens, Anthony Ollivier, Marine Rey, Éric Léonel
Abstract
Mild experimental conditions for a direct phosphonylation of an easily cleavable N-carbamate-tetrahydroisoquinoline have been described under constant current electrolysis. The developed electrochemical process allowed to prepare α-aminophosphonates in moderate to good yields. On the basis of the experimental results, a mechanism proceeding through a convergent paired electrochemical process was enabled to be postulated.
Topics & Concepts
ChemistryElectrolysisCarbamateElectrochemistryTetrahydroisoquinolineCombinatorial chemistryStereochemistryOrganic chemistryPhysical chemistryElectrodeElectrolyteOrganophosphorus compounds synthesisSulfur-Based Synthesis TechniquesAsymmetric Hydrogenation and Catalysis