Upregulation of serum and glucocorticoid-regulated kinase 1 exacerbates brain injury and neurological deficits after cardiac arrest
Reggie Hui‐Chao Lee, Mychal S. Grames, Celeste Yin‐Chieh Wu, Chih-Feng Lien, Alexandre Couto e Silva, HarLee E. Possoit, Garrett A. Clemons, Cristiane T. Citadin, Jake T. Neumann, Donatella Pastore, Davide Lauro, David Della‐Morte, Hung Wen Lin
Abstract
Upregulation of SGK1 exacerbates brain injury during cerebral ischemia. Inhibition of SGK1 affords neuroprotection against cardiac arrest-induced hypoperfusion, neuroinflammation, neuronal cell death, and neurological deficits.
Topics & Concepts
Downregulation and upregulationGlucocorticoidMedicineKinaseInternal medicineNeurosciencePsychologyChemistryBiologyGeneCell biologyBiochemistryCardiac Arrest and ResuscitationCardiac Ischemia and ReperfusionAnesthesia and Neurotoxicity Research