Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal
Huiyun Liu, Daniel Heller-Trulli, Claire Moore
Abstract
in triple-negative breast cancer cells. In addition, genetic overexpression of CPSF73 promoted breast cancer stemness and knocking down CPSF73 inhibited stem cell renewal properties. Together, our findings indicate that targeting the pre-mRNA processing nuclease CPSF73 has potential for breast cancer therapy.
Topics & Concepts
Ubiquitin ligaseBiologyNucleaseCancer researchUbiquitinDownregulation and upregulationCell biologyMessenger RNAStem cellProteasomeMolecular biologyGeneGeneticsRNA modifications and cancerRNA Research and SplicingRNA and protein synthesis mechanisms