Differential Pressures of SERINC5 and IFITM3 on HIV-1 Envelope Glycoprotein over the Course of HIV-1 Infection
Saina Beitari, Qinghua Pan, Andrés Finzi, Chen Liang
Abstract
HIV-1 Env protein is exposed to the inhibition not only by humoral response, but also by host restriction factors, including serine incorporator 5 (SERINC5) and interferon-inducible transmembrane 3 (IFITM3). This study investigates how HIV-1 envelope glycoprotein (Env) manages to overcome the pressures from all these different host inhibition mechanisms over the long course of viral infection. HIV-1 Env preserves the resistance to SERINC5 but becomes sensitive to IFITM3 when infection progresses into the chronic stage. Our study also supports the possibility of using CD4 mimetic compounds to sensitize HIV-1 Env to the inhibition by SERINC5 as a potential therapeutic strategy.
Topics & Concepts
BiologyGlycoproteinHuman immunodeficiency virus (HIV)Envelope (radar)VirologyDifferential (mechanical device)Cell biologyViral envelopeMolecular biologyPhysicsComputer scienceThermodynamicsRadarTelecommunicationsHIV Research and TreatmentMosquito-borne diseases and controlinterferon and immune responses