Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators
Jennifer M. Clark, Fernando Salgado-Polo, Simon J. F. Macdonald, Tim N. Barrett, Anastassis Perrakis, Craig Jamieson
Abstract
internalization, in line with the observed reduction in downstream signaling cascades and chemotaxis induction. These novel type V ATX inhibitors represent a promising tool to inactivate the ATX-LPA signaling axis.
Topics & Concepts
AutotaxinLysophosphatidic acidAllosteric regulationChemistryLysophosphatidylcholineSignal transductionBiochemistryEnzymeCell biologyPhospholipidReceptorBiologyPhosphatidylcholineMembraneSphingolipid Metabolism and SignalingEndoplasmic Reticulum Stress and DiseaseResearch on Leishmaniasis Studies