Characterization of KPC-82, a KPC-2 Variant Conferring Resistance to Ceftazidime-Avibactam in a Carbapenem-Nonsusceptible Clinical Isolate of Citrobacter koseri
François Lebreton, Brendan W. Corey, Christi L. McElheny, Alina Iovleva, Lan N. Preston, Katie R. Margulieux, Robert J. Cybulski, Patrick McGann, Yohei Doi, Jason W. Bennett
Abstract
KPC-82 is a KPC-2 variant identified in a carbapenem-nonsusceptible Citrobacter koseri that confers high-level resistance to ceftazidime-avibactam. Genomic analysis revealed that bla KPC-82 is carried by a chromosomally integrated Tn 4401 transposon (disrupting porin gene phoE ) and evolved by a 6-nucleotide tandem repeat duplication causing a two-amino-acid insertion (Ser-Asp) within the Ala 267 -Ser 275 loop.
Topics & Concepts
Ceftazidime/avibactamBiologyCarbapenemMicrobiologyMeropenemGeneticsEnterobacteriaceaeAntibiotic resistanceGeneEscherichia coliAntibioticsAntibiotic Resistance in BacteriaInfections and bacterial resistanceBacterial biofilms and quorum sensing