Limonin relieves TGF-β-induced hepatocyte EMT and hepatic stellate cell activation in vitro and CCl4-induced liver fibrosis in mice via upregulating Smad7 and subsequent suppression of TGF-β/Smad cascade
Guangwen Shu, Chenxi Dai, Arslan Yusuf, Hui Sun, Xukun Deng
Topics & Concepts
SMADDownregulation and upregulationHepatic stellate cellHepatocyteChemistryCancer researchLimoninPhosphorylationFibrosisBiologyIn vitroInternal medicineEndocrinologyMedicineBiochemistryGeneLiver physiology and pathologyPhytochemical compounds biological activitiesCoagulation, Bradykinin, Polyphosphates, and Angioedema