Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age
Elisa Russo, Giovanna Leoncini, Pasquale Esposito, Giacomo Garibotto, Roberto Pontremoli, Francesca Viazzi
Abstract
Recently, there has been a growing interest in epidemiological and clinical studies supporting a pathogenetic role of fructose in cardio-metabolic diseases, especially in children and adolescents. In the present review, we summarize experimental data on the potential biological mechanisms linking fructose and uric acid in the development of insulin resistance, metabolic syndrome, obesity, diabetes, hypertension, non-alcoholic fatty liver disease and chronic renal disease, thereby contributing to an increase in cardiovascular risk at pediatric age.
Topics & Concepts
Uric acidMetabolic syndromeInsulin resistanceMedicineDiabetes mellitusFatty liverDiseaseFructoseEpidemiologyObesityInternal medicineEndocrinologyPhysiologyBiologyBiochemistryDiet, Metabolism, and DiseaseLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects