Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells
Laura M. McLane, Shin Foong Ngiow, Zeyu Chen, John Attanasio, Sasikanth Manne, Gordon Ruthel, Jennifer E. Wu, Ryan P. Staupe, Wei Xu, Ravi K. Amaravadi, Xiaowei Xu, Giorgos C. Karakousis, Tara C. Mitchell, Lynn M. Schuchter, Alexander C. Huang, Bruce D. Freedman, Michael R. Betts, E. John Wherry
Abstract
biology.
Topics & Concepts
Transcription factorNuclear transportCD8BiologyCell biologyRepressorNuclear localization sequenceLymphocytic choriomeningitisCancer researchGeneCell nucleusGeneticsImmune systemImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses