Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis
Haiou Yang, Haiyang Zhang, Yuchong Yang, Xinyi Wang, Ting Deng, Rui Liu, Tao Ning, Ming Bai, Hongli Li, Kegan Zhu, Jialu Li, Qian Fan, Guoguang Ying, Yi Ba
Abstract
Hypoxia-derived exosomal circ-133 transported into normaxic cancer cells and promoted cell migration via miR-133a/GEF-H1/RhoA axis. This study reveals a potential mechanism for that the intra-tumor heterogeneity of oxygen promote cancer progression.
Topics & Concepts
RHOAMicrovesiclesMetastasisCancer researchCancer cellExosomeHypoxia (environmental)Tumor progressionGene knockdownCancerChemistryPathologyMedicineApoptosisSignal transductionmicroRNAInternal medicineOxygenBiochemistryGeneOrganic chemistryCircular RNAs in diseasesExtracellular vesicles in diseaseMicroRNA in disease regulation